Concordance of Molecular Classification Based on Fine Needle Biopsy (FNB) and Surgical Samples

Participation Requirements

• Sex:

  ALL

• Eligible Ages:

  18 and up

Participation Criteria

Inclusion Criteria:

* Age ≥ 18 years
* A diagnosis of papillary thyroid cancer based on a fine needle biopsy (FNB) interpreted as a Bethesda V or VI cytology
* A diagnosis of Atypia of Undetermined Significance (AUS) or Follicular Lesion of Undetermined Significance (FLUS) interpreted as Bethesda III or IV cytology (indeterminate nodule) ThyroSpec positive for BRAFV600E, TERT, rearrangements in BRAF, RET, NTRK1, NTRK3, RAS + TERT, RAS + EIF1AX, AKT1, PI3CA, CTNNB1, EGFR, rearrangements in ALK
* Tumor size \> 1 cm in maximal diameter on imaging prior to surgery
* The patient is an operative candidate
* The patient has provided consent

Exclusion Criteria:

* History of radiation to the neck for situations such as medical radiation, radiation exposure in a work environment (nuclear power plant/reactor), or radiation exposure through release of radioactive materials into the nearby environment from a nuclear power plant/reactor.
* Unable or unwilling to have a fine needle biopsy
* Unwilling to undergo thyroidectomy
* Final pathology does not demonstrate papillary thyroid cancer
* Cases where there is no clear dominant nodule
* Cases where there are multiple nodules that preclude sampling of a defined nodule