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Study of Food Aversion in Patients With Anorexia Nervosa

Anorexia Nervosa

This study uses a meal-challenge protocol to assess if patients with anorexia nervosa show a differential metabolism in response to food in comparison to healthy controls. This study determines how heritable and biochemical factors influence food metabolism in anorexia nervosa in order to develop more effective treatment strategies.

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Participation Requirements

  • Sex:

    FEMALE

  • Eligible Ages:

    18 to 55

Participation Criteria

Inclusion Criteria:

* Ill AN subjects will meet current Diagnostic and Statistical Manual of Mental Disorders (DSM V) diagnosis of AN, body mass index (BMI) between 11 kg/m² and 17.5 kg/m², or BMI \> 17.5 kg/m² with active eating disorder symptoms.
* Recovered AN must meet the following criteria at time of study entry: 1) Current or past DSM V diagnosis of AN; 2) BMI between 18.5 kg/m2 and 30 kg/m2; 3) Having maintained a BMI of \>18.5 for at least one year.
* Control must be healthy adolescent or woman negative on our screen for AN, other Axis I psychiatric illnesses, and having maintained a BMI of between 18.5-30 kg/m² since the age of 18.

Exclusion Criteria:

* Exclusion criteria for AN and control subjects include: Organic brain syndrome, schizophrenia and schizoaffective disorder, untreated thyroid disease, renal disease, hepatic disease, and the regular use of fish-oil containing supplements within the last three months of the study. All pregnant and lactating individuals will be excluded.

Study Location

Program for Eating Disorders, Toronto General Hospital
Program for Eating Disorders, Toronto General Hospital
Toronto, Ontario
Canada

Contact Study Team

Backup Contact

D. Blake Woodside, MD FRCPC

[email protected]
416-340-4445
Primary Contact

D. Blake Woodside

[email protected]
416-340-4445
Study Sponsored By
University of California, San Diego
Participants Required
More Information
Study ID: NCT03100656