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Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients

Nervous System Diseases | Neurologic Manifestations | Neurocognitive Disorders | Delirium | Confusion |...

Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated. However, many patients have persistent memory impairment for weeks to months after surgery. Cardiac surgery appears to carry the highest risk of postoperative cognitive dysfunction (POCD). These cognitive deficits are associated with increased mortality, prolonged hospital stay and loss of independence. The investigators propose to investigate the role of Dexmedetomidine (DEX) in preventing long-term POCD after cardiac surgery and enhancing early postoperative recovery. It is anticipated that DEX will be the first effective preventative therapy for POCD, improve patient outcomes, and reduce length of stay and healthcare costs.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    60 and up

Participation Criteria

Inclusion Criteria:

* Planned CABG (+/- valve, including off-pump) or valve replacement via sternotomy/thoracotomy, with initial recovery in the Cardiovascular Intensive Care Unit (CVICU)
* Age ≥60

Exclusion Criteria:

* Lack of patient consent
* Pre-operative major cognitive dysfunction (CogState Brief Battery score \< 80) at screening
* Aortic arch replacement/re-implantation (surgery requiring hypothermic circulatory arrest, e.g. Bentall procedure)
* Allergy/contraindication to dexmedetomidine (untreated 2nd degree type 2 or 3rd degree heart block (pacemaker), cirrhosis, HR \< 50 , grade 4 LV, renal failure or on renal replacement therapy)
* Unlikely to comply with study assessments (e.g. no fixed address, cannot complete cognitive tests at the 3, 6, and 12 month time points)

Study Location

Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Lilia Kaustov, PhD

[email protected]
416-480-6100
London Health Sciences
London Health Sciences
London, Ontario
Canada

Contact Study Team

Laval University
Laval University
Québec, Quebec
Canada

Contact Study Team

Primary Contact

Francois Laforge

[email protected]
Royal Columbian Hospital
Royal Columbian Hospital
Vancouver, British Columbia
Canada

Contact Study Team

St. Michael's Hospital
St. Michael's Hospital
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Sanjay Yagnik

[email protected]
St. Paul's Hospital
St. Paul's Hospital
Vancouver, British Columbia
Canada

Contact Study Team

Toronto General Hospital
Toronto General Hospital
Toronto, Ontario
Canada

Contact Study Team

University of Saskatchewan
University of Saskatchewan
Saskatoon, Saskatchewan
Canada

Contact Study Team

Study Sponsored By
Sunnybrook Health Sciences Centre
Participants Required
More Information
Study ID: NCT04289142