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Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia

Congenital Diaphragmatic Hernia

CDH is associated with lung hypoplasia, pulmonary hypertension, and left ventricular hypoplasia.

Use of new STE techniques (heart ultrasound) showed that CDH newborns have decreased LV size and function, potentially explaining the non-response to iNO, and that these cardiac findings were associated with poor outcomes. Our hypothesis: CDH newborns persist to have some degree of LV hypoplasia in the pediatric and adolescent life and pulmonary pressures remain increased during growth. Patients with decreased cardiac performance by STE and/or with PH have higher concomitant neonatal or pediatric morbidities and altered neurodevelopmental profile

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    0 to 17

Participation Criteria

Inclusion:

* CDH patients admitted to the MCH-NICU
* CDH followed at the MCH CDH clinic

Exclusion:

* Prematurity (\< 36 weeks)
* Diagnosis at \> 7 days of life
* Bilateral CDH
* Congenital cardiac defect (excluding a patent ductus arteriosus (PDA), atrial septal defect (ASD) or ventricular septal defect (VSD)) and/or other major anomaly/genetic syndrome.

Study Location

Mcgill University Health Centre
Mcgill University Health Centre
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Gabriel Altit, MD

[email protected]
514-412-4452
Study Sponsored By
McGill University Health Centre/Research Institute of the McGill University Health Centre
Participants Required
More Information
Study ID: NCT04114578