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Reversal of Atrial Substrate to Prevent Atrial Fibrillation Cohort Study

Atrial Fibrillation, Paroxysmal or Persistent

Atrial fibrillation (AF) is a major health problem, with a prevalence of 0.4-1% of the population. It results in high healthcare costs and significant morbidity, especially for patients with severe symptoms. The RASTA-AF randomized control trial (RCT) is designed to answer the following question: does vigorous treatment of AF with aggressive risk factor management plus catheter ablation reduce AF-related outcomes as compared to catheter ablation plus usual care in patients with symptomatic AF and risk factors that promote AF.

This study is a multicenter, prospective cohort study that will enrol patients who decline participation in the RASTA-AF RCT but agree to be followed in a registry. The objective of RASTA-Cohort is to determine whether patients who decline participation in the RASTA-AF RCT have different clinical characteristics and quality of life than patients who accept participation in the study, and whether they suffer from worse AF-related outcomes than patients in the RCT.

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Participation Requirements

  • Sex:

    ALL
  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* symptomatic AF (CCS-SAF ≥2),
* paroxysmal or persistent atrial fibrillation despite rate control, desiring catheter ablation and either: i) BMI ≥ 30 or, ii) at least two of the following: BMI\>27, BP\>140/90 mmHg or history of hypertension, Diabetes, Heart failure (prior heart failure admission or LVEF\<40%), Age ≥ 65 years, Prior stroke/TIA, Current smoker, Excessive alcohol use {For women: 10 or more drinks/week, more than 2 drinks a day (most days). For men: 15 or more drinks/week, more than 3 drinks a day (most days)}, and iii) declined or were not approached for participation in the main study. Eligible patients must have received catheter ablation for AF during the same timeline of the RASTA-AF Mian Study (November 1st, 2019 to December 31st, 2025).

Exclusion Criteria:

* permanent AF (AF lasting \> 3 years),
* prior catheter ablation for AF
* New York Heart Association Class IV heart failure
* participation in a cardiac rehabilitation program within the last year,
* currently performing exercise training \>150 minutes/week of moderate to vigorous physical activity,
* unable to exercise,
* unable to give informed consent,
* other noncardiovascular medical condition making 1 year survival unlikely
* less than 18 years of age

Study Location

QEIIHSC
QEIIHSC
Halifax, Nova Scotia
Canada

Contact Study Team

Foothills Hospital
Foothills Hospital
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Jennifer McKeage

Sunnybrook Hospital
Sunnybrook Hospital
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Ambreen Syeda

London Health Sciences Centre
London Health Sciences Centre
London, Ontario
Canada

Contact Study Team

Primary Contact

Keza Motlana

Regina General Hospital
Regina General Hospital
Regina, Saskatchewan
Canada

Contact Study Team

Primary Contact

Maria Gagarinova

University of Ottawa Heart Institute
University of Ottawa Heart Institute
Ottawa, Ontario
Canada

Contact Study Team

Primary Contact

Tammy Knight

Montreal Heart Institute
Montreal Heart Institute
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Caroline Girard

Study Sponsored By
Nova Scotia Health Authority
Participants Required
More Information
Study ID: NCT06249269