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A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

Non-small Cell Lung Cancer (NSCLC) | High-grade Serous Ovarian Carcinoma (HGSOC) | Uterine Serous Carcinoma (USC)

The purpose of this study is to evaluate the safety, tolerability, and efficacy of escalating doses of BMS-986463 in participants with select advanced malignant tumors.

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Participation Requirements

  • Sex:

    ALL
  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria

* Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1.
* Participants must have at least 1 lesion accessible for biopsy in addition to the target lesion, from which a fresh pre treatment biopsy must be obtained.
* Participants must have an unresectable/metastatic carcinoma.

Exclusion Criteria

* Participants must not have Leptomeningeal metastases.
* Participants must not have concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment.
* Participants must not have had any prior radiation therapy within 2 weeks prior to start of study treatment.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Study Location

Jewish General Hospital
Jewish General Hospital
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Susie Lau, Site 0024

5143408222ext23114
Local Institution - 0027
Local Institution - 0027
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Site 0027

BC Cancer Vancouver
BC Cancer Vancouver
Vancouver, British Columbia
Canada

Contact Study Team

Primary Contact

Yvette Drew, Site 0026

604-877-6000
Study Sponsored By
Bristol-Myers Squibb
Participants Required
More Information
Study ID: NCT06476808