A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.
Non-small Cell Lung Cancer (NSCLC) | High-grade Serous Ovarian Carcinoma (HGSOC) | Uterine Serous Carcinoma (USC)The purpose of this study is to evaluate the safety, tolerability, and efficacy of escalating doses of BMS-986463 in participants with select advanced malignant tumors.
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Participation Requirements
-
Sex:
ALL -
Eligible Ages:
18 and up
Participation Criteria
Inclusion Criteria
* Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1.
* Participants must have at least 1 lesion accessible for biopsy in addition to the target lesion, from which a fresh pre treatment biopsy must be obtained.
* Participants must have an unresectable/metastatic carcinoma.
Exclusion Criteria
* Participants must not have Leptomeningeal metastases.
* Participants must not have concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment.
* Participants must not have had any prior radiation therapy within 2 weeks prior to start of study treatment.
* Other protocol-defined Inclusion/Exclusion criteria apply.
Study Location
Jewish General Hospital
Jewish General HospitalMontreal, Quebec
Canada
Contact Study Team
Susie Lau, Site 0024
5143408222ext23114Local Institution - 0027
Local Institution - 0027Toronto, Ontario
Canada
Contact Study Team
Site 0027
BC Cancer Vancouver
BC Cancer VancouverVancouver, British Columbia
Canada
Contact Study Team
Yvette Drew, Site 0026
604-877-6000- Study Sponsored By
- Bristol-Myers Squibb
- Participants Required
- More Information
- Study ID:
NCT06476808