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Exercise and Cognitive (Brain) Function in Breast Cancer Patients Getting Chemotherapy After Breast Surgery

Breast Cancer

This study will primarily identify longitudinal associations between cardiorespiratory fitness (CRF) and cognitive function pre- (baseline) to post-chemotherapy (\~3 months). This will be a prospective study of 50 BCS. We hypothesize that breast cancer patients undergoing chemotherapy who have higher levels of CRF at baseline will have significantly improved measures of attention, executive function, and memory post-chemotherapy. In addition, the exploratory aims will examine the longitudinal associations between physical activity (PA) and cognitive function from pre- to post-chemotherapy and explore the associations between inflammatory and non-inflammatory biomarkers and CRF with cognitive function.

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Participation Requirements

  • Sex:

    FEMALE

  • Eligible Ages:

    18 to 65

Participation Criteria

Inclusion Criteria:

* 18-65 years old
* histologically-confirmed stage I-III breast cancer, but prior to the initiation of chemotherapy (\<1 cycle of adjuvant therapy or neoadjuvant therapy)
* no diagnosed major cognitive disorders and uncontrolled comorbidities.

Exclusion Criteria:

* received neoadjuvant chemotherapy and scheduled to receive adjuvant chemotherapy
* scheduled to receive concurrent radiation therapy with chemotherapy.

Study Location

Sunnybrook Health Sciences Centre-Odette Cancer Centre
Sunnybrook Health Sciences Centre-Odette Cancer Centre
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Ellen Warner, MD

Study Sponsored By
University of Toronto
Participants Required
More Information
Study ID: NCT04616300