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The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency

Premature Ovarian Failure | Primary Ovarian Insufficiency

The goal of this pilot study is to improve ovarian reserve markers in patients with premature ovarian insufficiency. The main question it aims to answer is:

- Will treatment with G-CSF allow improvement in markers of ovarian reserve?

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Participation Requirements

  • Sex:

    FEMALE

  • Eligible Ages:

    25 to 40

Participation Criteria

Inclusion Criteria:

* Women ages 25-40
* Woman who meet criteria for POI defined as AFC \< 5, AMH \< 3 pmol/L and FSH \>30 IU/L. There may also be associated symptoms of the menopause such as hot flushes, night sweats, insomnia and vaginal dryness.
* Women who are not taking any other medical or fertility treatments except natural estrogen to stop hot flushes.
* Those who are provided with informed consent.

Exclusion Criteria:

* Women with age \> 40
* Women with history of autoimmune disorders
* Women with a history of hematopoietic cell malignancies
* Women with sickle cell disease
* Women with any other comorbidities that would preclude infertility treatment and pregnancy such as HIV/AIDS, hepatitis B or C, breast cancer or body mass index (BMI) \>40.

Study Location

Trio Fertility
Trio Fertility
Toronto, Ontario
Canada

Contact Study Team

Backup Contact

Yasaman Sadeghi, M.Sc.

[email protected]
416-506-0804
Primary Contact

Robert. F. Casper, Dr.

[email protected]
416-506-0804
Study Sponsored By
Trio Fertility
Participants Required
More Information
Study ID: NCT06117982