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Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion

Trigeminal Neuralgia

The aim of this study is to assess the feasibility of deep brain stimulation for refractory trigeminal neuralgia due to a pontine lesion, as is usually seen in the context of multiple sclerosis.

These patients usually have severe intractable facial pain and current medical and surgical options generally fail to achieve long lasting pain relief.

Hoping to improve pain control in this population, the investigators of this trial propose a novel technique consisting of implanting a deep brain stimulation lead within the pontine lesion to modulate the generation of pain signals.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* Adults of at least 18 years old
* Refractory trigeminal neuralgia : failure of at least 3 drugs and at least two lesioning surgical interventions (radiosurgery, percutaneous rhizotomy, or open rhizotomy).
* Pontine lesion proved by MRI in contact with trigeminal nerve tract

Exclusion Criteria:

* Absolute contraindication to MRI
* Medical contraindication to the procedure

Study Location

Centre Hospitalier Universitaire de Sherbrooke (CHUS)
Centre Hospitalier Universitaire de Sherbrooke (CHUS)
Sherbrooke, Quebec
Canada

Contact Study Team

Primary Contact

Mélodie Grondin-Lavigne, MD MSc candidate

[email protected]
819-346-1110
Study Sponsored By
Université de Sherbrooke
Participants Required
More Information
Study ID: NCT05451251