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Delineating Between Pathophysiologic Phenotypes of Hypoxic Ischemic Brain Injury After Cardiac Arrest

Hypoxia-Ischemia, Brain

The main outcome determinant following cardiac arrest is hypoxic ischemic brain injury. Management has involved increasing the delivery of oxygen to the brain. This logic assumes that oxygen transport from blood into the brain is normal. We have demonstrated that this assumption is not true. A large proportion of post-cardiac arrest patients demonstrate an inability to unload oxygen into the brain. The mechanisms explaining this observation are unclear. This project involves using a series of evaluations to differentiate post-cardiac arrest patients who exhibit normal and abnormal oxygen transport dynamics and also investigate the underlying mechanisms for abnormal oxygen transport.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    19 and up

Participation Criteria

Inclusion Criteria:

* 1) Greater than 19 years old post cardiac arrest with a Glasgow Coma Scale of 8 or less
* 2) Invasive monitoring implemented within 72 hours of cardiac arrest
* 3) Duration of cardiac arrest greater than 10 minutes.

Exclusion Criteria:

* 1) Coagulopathy (INR \> 1.5, PTT \> 40, Platelets \< 100x106 per microliter)
* 2) Current or anticipated use of anticoagulant or antiplatelet medication
* 3) Target temperature under 35oC; 4) history of severe TBI, intracranial hemorrhage or stroke.

Study Location

Vancouver General Hospital
Vancouver General Hospital
Vancouver, British Columbia
Canada

Contact Study Team

Primary Contact

Mypinder Sekhon

[email protected]
Study Sponsored By
University of British Columbia
Participants Required
More Information
Study ID: NCT05390060