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Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents With Anxiety and Depression

Anxiety and Depression

This is a parallel arm randomized (1:1) controlled trial. Adolescents aged 12-17 years (n=452) who are starting or changing a selective serotonin reuptake inhibitor (SSRI) for depression and/or anxiety will be randomly allocated to receive 12-weeks of pharmacogenetic-guided antidepressant therapy (experimental intervention) or current prescribing guidelines/recommendations guided therapy (control intervention).

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    12 to 17

Participation Criteria

Inclusion Criteria:

* Age 12-17
* Depression and/or anxiety as the primary concern, confirmed by the treating physician
* Intention to start a new SSRI
* English fluency

Exclusion Criteria:

* Co-occurring obsessive compulsive disorder, psychosis, bipolar disorder, eating disorder, autism spectrum disorder, fetal alcohol spectrum disorder, or intellectual disability
* History of non-response to 3 or more SSRI medications as confirmed by the treating physician
* Brain stimulation-based therapy initiated within 8 weeks of referral, or plans to initiate/change brain stimulation during study participation
* History of liver or hematopoietic cell transplant
* History of CYP2B6, CYP2C19, or CYP2D6 testing

Study Location

University of Calgary
University of Calgary
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Laina McAusland, MSc

[email protected]
403-210-6353
Study Sponsored By
University of Calgary
Participants Required
More Information
Study ID: NCT06853587