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Single Anastomosis Versus Standard Duodenal Switch

Obesity | Morbid Obesity

Bilio-Pancreatic diversion with Duodenal Switch (BPD-DS) is the most effective bariatric procedure in terms of long-term weight loss and remission rate of Type 2 Diabetes. However, its technical difficulty and increased risk of long-term nutritional deficiencies have been a major hindrance to its diffusion.

Recently, a " simplified " technique of Duodenal-Switch has been proposed by Sanchez-Pernaute et al. This technique involves the creation of a Sleeve Gastrectomy, transection of the first duodenum, and connection of the duodenum to an omega-loop of small bowel instead of a terminal intestinal loop used in standard BPD-DS.

The overall objective of this study is to assess in a prospective randomized blinded trial, the outcomes of this new procedure, using a comprehensive clinical evaluation and follow-up method. This could potentially change the clinical practice and surgical approach in our Institution.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 to 60

Participation Criteria

Inclusion Criteria:

* Age ≥18 years and ≤60 years
* Fulfill criteria for bariatric surgery as coined by National Institutes of Health BMI≥35
* Give written informed consent

Exclusion Criteria:

Participants who meet any of the following criteria at the time of the baseline visit are excluded from the study:

* Presence of the following baseline comorbidities:
* Inflammatory bowel disease (IBD),
* Cirrhosis
* History of gastric or duodenal ulcers
* Preoperative hypoalbuminemia (\<35 g/L)
* History of severe renal, hepatic, cardiac or pulmonary disease
* Past esophageal, gastric or bariatric surgery
* Type 1 Diabetes
* Pregnancy
* Evidence of psychological problem that may affect the capacity to understand the project and to comply with the medical recommendations
* History of drug use or alcohol abuse in the last 6 months
* History of gastro-intestinal inflammatory diseases

Study Location

Institut Universitaire de Cardiologie et de Pneumologie de Québec
Institut Universitaire de Cardiologie et de Pneumologie de Québec
Quebec City, Quebec
Canada

Contact Study Team

Primary Contact

Suzy Laroche

[email protected]
418-656-8711
Study Sponsored By
Laval University
Participants Required
More Information
Study ID: NCT04767490