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Feasibility of Reducing Respiratory Drive Using the Through-flow System

Respiratory Insufficiency | Lung Injury | Diaphragm Injury

Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury. Mechanical stress and strain applied by mechanical ventilation or by the patient's own respiratory muscles can also cause injury to the lungs. Diaphragm and lung injury are associated with increased morbidity and mortality. Throughflow is a novel system that can reduce dead space without the need to increase the tidal ventilation, reducing the ventilatory demands and respiratory drive.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* PaO2/FiO2 less than or equal to 300 at time of screening
* Oral endotracheal intubation with ETT 7.5 or 8.0 and on invasive mechanical ventilation
* Bilateral airspace opacities on chest radiograph or chest CT scan

Exclusion Criteria:

* Contraindication to esophageal catheterization (upper gastrointestinal tract surgery within preceding 6 weeks, bleeding esophageal/gastric varices)
* Intubation for traumatic brain injury or stroke
* Intracranial hypertension (suspected or diagnosed by medical team)
* Anticipated liberation from mechanical ventilation within 24 hours

Study Location

University Health Network
University Health Network
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Cindy Jin

[email protected]
Study Sponsored By
University Health Network, Toronto
Participants Required
More Information
Study ID: NCT05642832