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Feasibility of Different Types of Exercise Training in Perimenopausal Females

Women

Throughout the menopause transition, women experience many symptoms (i.e., hot flashes, night sweats) that can significantly reduce their quality of life. Moreover, their risk of heart disease increases substantially. The years before menopause called "perimenopause" present a critical window of intervention to alleviate menopause symptoms and improve health outcomes. Our team is therefore interested in comparing the potential benefits of different approaches including following the Health Canada guidelines (i.e., accumulating 150 min of moderate-to-vigorous aerobic physical activity weekly); performing high-intensity interval training (HIIT), which involves alternating periods of intense exercise with periods of rest; or stretching in perimenopause. As a first step towards this goal, this study will assess how easy and enjoyable the interventions are to follow over a 6-week period. The information gained from this study will be used to perform a larger study with enough participants to assess the health and quality of life impacts of adopting these different strategies in perimenopause.

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Participation Requirements

  • Sex:

    FEMALE

  • Eligible Ages:

    40 and up

Participation Criteria

Inclusion Criteria:

* Biological females in early and late perimenopause. Menopausal stage will be defined according to the Stages of Reproductive Aging Workshop +10 (STRAW+10). According to STRAW+10, perimenopause is characterized by menstrual cycle irregularity, specifically defined as having bleeding in the previous 12 months but at least a 7-day difference from usual menstrual cycle length
* Experiencing menopause symptoms (e.g., hot flashes, night sweats, joint stiffness)
* Aged 40 years or older
* Multiple risk factors for cardiometabolic disease, namely being sedentary (\<30 min of moderate-vigorous physical activity/week), having a BMI ≥25 kg/m2, and a waist circumference indicative of abdominal obesity, specific to BMI (e.g., BMI 25-29.9: WC: 90cm; BMI 30-34.9: WC: 105cm; BMI 35-35.9: WC:115cm).

Exclusion Criteria:

* History of reproductive surgeries including oophorectomy, hysterectomy, ablation or gender-affirming.
* Diagnosis of cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease, cancer (except for non-melanoma skin cancer), respiratory disease (e.g., Chronic Obstructive Pulmonary Disease or severe or uncontrolled asthma), uncontrolled hyper- or hypogonadism (change in medication or dosage in last 6 months and with major symptoms), and/or Polycystic Ovary Syndrome
* Major signs or symptoms (regardless of known diagnosis) of cardiovascular diseases, diabetes, or renal disease
* The use of medication that could impact blood glucose
* Pregnant or post-partum \<12 months, lactating or breast feeding within 3 months of the start of study
* Recreational smoking (e.g., tobacco, smoking)
* Actively engaging in a low-carbohydrate diet (e.g., ketogenic, Atkins)
* Using transdermal hormones, taking exogenous hormones, or receiving exogenous hormones from other means (e.g., intrauterine device)
* Significant weight loss (i.e., \>5 kg) in past 3 months or currently taking weight loss medications

Study Location

Goldring Centre for High Performance Sport
Goldring Centre for High Performance Sport
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Jenna Gillen, PhD

[email protected]
4169783244
Study Sponsored By
University of Toronto
Participants Required
More Information
Study ID: NCT07132385