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COgnitioN with VERiciGuat Evaluation in Heart Failure

Cognitive Impairment | Heart Failure | Memory Problems

This study, called CONVERGE-HF, is looking at a Health Canada approved drug called Vericiguat to see if it can help people who have heart failure and some memory problems. The study will compare Vericiguat to the usual heart failure medications people get. The researchers want to see how well Vericiguat works by looking at brain and heart images, blood tests, physical and mental abilities, quality of life, and any health problems that come up. Participants will take Vericiguat or the usual treatment for approximately 6 months.

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Participation Requirements

  • Sex:

    Any

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:
Age- 18-90 years

Established chronic heart failure (≥6months)

Mild-to-moderate cognitive impairment (as per the diagnosis of cognitive impairment or a Montreal Cognitive Assessment (MoCA) score 10-25).
Exclusion Criteria:
Patients who have contraindications for vericiguat therapy (i.e.use of long- acting nitrates, other soluble guanylate cyclase stimulators (e.g., riociguat), or phosphodiesterase type 5 (PDE-5), pregnancy or breast-feeding.
Unable to undergo Cardiac Magnetic Resonance Imaging (MRI) or brain MRI, implantable cardiac device (ICD or CRT), uncontrolled atrial fibrillation or recurrent ventricular arrhythmias.
General medical conditions:uncontrolled thyroid disorders, liver failure, or recent (previous 3 months) myocardial coronary angioplasty and/or heart surgery, cancer/malignancy, or severe dementia.
Allergies to the study drug.
Currently hospitalized.

Study Location

University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Quentin Kushnerik

[email protected]
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Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: Pro00146022