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Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury

Hemodialysis | Cardioprotection

The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment. Will pre-dialysis exercise protect the heart from a decrease in pumping of the heart muscle (called stunning) that can happen during hemodialysis. We will study whether pre-dialysis exercise decreases heart stunning, decreases the number and severity of symptoms commonly associated with hemodialysis, and other outcomes

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 to 79

Participation Criteria

Inclusion Criteria:

* must be on chronic hemodialysis for at least 3 months
* age 18 years or older
* willing and able to provide informed consent
* assessed to be safe and able to exercise by unit HD Nephrologist

Exclusion Criteria:

* regular vigorous exercise outside of hemodialysis
* over 79 years of age
* intradialytic exercise \< 3 months
* poor echogenicity
* acute coronary syndrome in the past 3 months
* unstable arrhythmia/angina
* shortness of breath at rest or with minimal activity
* symptomatic hypoglycemia (\>2x/week in the week prior to enrolment)

Study Location

London Health Sciences Centre
London Health Sciences Centre
London, Ontario
Canada

Contact Study Team

Study Sponsored By
London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's
Participants Required
More Information
Study ID: NCT06735378