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Prehabilitation for Colorectal Cancer Patients With Low Functional Capacity and Malnutrition

Malnutrition | Prehabilitation | Physical Functional Performance

Despite multi-modal prehabilitation (nutrition, exercise, and psychosocial interventions), 60% of older elective colorectal cancer surgery patients with poor physical function were unable to reach a minimum preoperative 400m six-minute walking distance (6MWD), a prognostic cut-point. Compared to the patients that attained \>400m 6MWD preoperatively, twice as many of \<400m patients were malnourished. Malnutrition has long been associated with worse functioning (e.g., physical, immune). The investigators hypothesize that for nutritionally deficient patients, the etiology for their poor physical function is malnutrition. Correction of malnutrition alone might thus be sufficient to achieve a 400m 6MWD before surgery and improve patient outcomes.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    65 and up

Participation Criteria

Inclusion Criteria:

* Patients aged 65 years and older;
* Patients with cancer scheduled for primary colorectal resection;
* Patients with 6MWD at baseline less than 400 m;
* Patients with Patient-Generated Subjective-Global Assessment (malnutrition assessment) score equal or greater than 9.

Exclusion Criteria:

* Patients with history of premorbid conditions that contraindicate exercise including dementia, -Parkinson's disease or previous stroke with paresis;
* Metastatic cancer;
* Patients who do not speak English or French and cannot be accompanied by someone who speaks English or French;

Study Location

MUHC Research Ethics Board
MUHC Research Ethics Board
Montréal, Quebec
Canada

Contact Study Team

Primary Contact

Elizabeth Craven, PhD

[email protected]
514 934-1934
Study Sponsored By
McGill University
Participants Required
More Information
Study ID: NCT05999370