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Lysine Requirements During Lactation

Breastfeeding | Breastfeeding, Exclusive | Lactation

The study aims to establish lysine requirements using the indicator amino acid oxidation (IAAO) method in women exclusively breastfeeding a single infant aged 3-4 months, and how maternal lysine needs change once infant transition to complimentary feeding at a later age of 9-10 months. Each 8-hour study day will have an assigned test lysine intake ranging from deficient to excess. The diets will be provided in a complete protein shake format, meeting all nutrient requirements except for the test lysine intake. Breath samples evaluate the indicator's oxidation to determine protein synthesis in response to lysine intake. Urine and one blood sample will be collected to assess metabolite concentrations.

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Participation Requirements

  • Sex:

    FEMALE

  • Eligible Ages:

    20 to 40

Participation Criteria

Inclusion Criteria:

* Healthy
* Female
* 20-40 years
* Had a singleton pregnancy and is breastfeeding a single child.
* Exclusively breastfeeding an infant 3 - 4 months of age OR complimentary. feeding an infant 9-10 months of age.

Exclusion Criteria:

* Participants not in good health or have a history of metabolic, cardiovascular, neurological, genetic, endocrine, immune, or physical mobility disorders.
* Participants that had major pregnancy or delivery complications (e.g., preeclampsia/ eclampsia, placenta previa, postpartum haemorrhage, neonatal intensive care, gestational diabetes).
* Participants with substance dependence issues (e.g., nicotine, alcohol, marijuana, illicit drugs).
* Participants that have had breast surgery that may impact lactation, lactogenesis or breastfeeding.
* Participants that use medications that affect lactation (e.g. estrogenic birth control, anti-dopaminergic drugs, Methyldopa) or other continuous prescription medication.
* Participants with a pre-pregnancy BMI below 18 kg/m² or above 28 kg/m².
* Participants who are below 20 years of age or greater than 40 years of age.
* Infants' weight and length are under 3rd or above the 97th percentile, using the World Health Organization (WHO) percentile growth chart.
* Infants born before 38 weeks or after 42 weeks of gestation.
* Infants who use infant formula milk.
* Infants with known metabolic, cardiovascular, neurological, genetic, endocrine, immune, or physical mobility disorders.

Study Location

BC Children's Hospital Research Institute
BC Children's Hospital Research Institute
Vancouver, British Columbia
Canada

Contact Study Team

Backup Contact

Rajavel Elango, PhD

Primary Contact

Taylor Bailey, BSc

[email protected]
705-698-7648
Study Sponsored By
University of British Columbia
Participants Required
More Information
Study ID: NCT06366204