Skip to content

Post Spinal Hemodynamic Changes in Aortic Stenosis and Mitral Regurgitation by VIS Index and Echocardiography

Severe Aortic Valve Stenosis | Severe Mitral Valve Regurgitation

This study will assess hemodynamic changes induced after spinal anesthesia by evaluating vasopressor inotropic requirements and variations in echocardiographic parameters in patients having severe aortic stenosis or severe mitral regurgitation undergoing aortic or mitral valve replacement surgery.

null

Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* All patients over 18 years of age, irrespective of their gender or ASA physical status
* With severe aortic stenosis or mitral regurgitation
* Undergoing elective aortic or mitral valve repair or replacement
* Eligible for spinal anesthesia up to T1-2 level block for their surgical procedure.
* Able to provide written informed consent

Exclusion Criteria:

* Contraindications to the administration of spinal anesthesia such as pre-existing coagulopathy, local sepsis at the site of insertion
* Hypoxic (SaO2 \< 95%) on room air
* Unable to lie flat and with 15-degree trendelenburg
* The apical four and five chamber window is not accessible on trans-thoracic echocardiography
* Difficult airway requiring awake intubation
* On dialysis
* Redo-valve surgery
* Mixed valvular lesions (more than mild AR or MS)
* Requiring more than one CABG or CPB duration more than 180 minutes
* More than 3 segment Regional Wall Motion Abnormalities
* Severe spine disorders

Study Location

Department of Anesthesiology, Perioperative and Pain Medicine, SBGH
Department of Anesthesiology, Perioperative and Pain Medicine, SBGH
Winnipeg, Manitoba
Canada

Contact Study Team

Primary Contact

Virendra Arya, MD, FRCPC

[email protected]
2048915671
Backup Contact

Linda Girling, BSc Hons

2047871414
Study Sponsored By
University of Manitoba
Participants Required
More Information
Study ID: NCT06156592