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MARINER Trial: Multiparametric Cardiac PET for CAV Surveillance After Heart Transplantation

Cardiac Allograft Vasculopathy

Cardiac allograft vasculopathy (CAV) is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. Surveillance for CAV is vital; however an ideal approach has not been established. The goal of this study is to assess whether noninvasive positron emission tomography (PET) based surveillance is non-inferior to invasive coronary angiography (ICA) surveillance.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

1. Post heart transplant 2-10 years.
2. Age ≥18 years.
3. Able to provide informed consent.

Exclusion Criteria:

1. Contraindication to dipyridamole due to severe aortic stenosis.
2. Contraindication to dipyridamole due to 2:1 or greater AV block without pacemaker.
3. Contraindication to dipyridamole due to severe bronchospasm.
4. Unable to undergo coronary angiography due to allergy to iodinated contrast.
5. Unable to undergo coronary angiography due to glomerular filtration rate ≤30 mL/min/1.73 m2. for non-dialysis patients as determined by local laboratory analysis.
6. Unable to undergo coronary angiography due to unsuitable vascular access.
7. Treated rejection ≤1-month.
8. Unstable angina or MI ≤7 days.

Study Location

University of Calgary
University of Calgary
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Robert Miller

Montreal Heart Institute
Montreal Heart Institute
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Tremblay-Gravel

Toronto-General Hospital - University Health Network
Toronto-General Hospital - University Health Network
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Heather Ross

Mazankowski Alberta Heart Institute
Mazankowski Alberta Heart Institute
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Daniel Kim

University of Ottawa Heart Institute
University of Ottawa Heart Institute
Ottawa, Ontario
Canada

Contact Study Team

Primary Contact

Sharon Chih

Study Sponsored By
Ottawa Heart Institute Research Corporation
Participants Required
More Information
Study ID: NCT06089486