Longitudinal 3He Magnetic Resonance Imaging of Healthy Lung

Participation Requirements

• Sex:

  ALL

• Eligible Ages:

  60 to 90

Participation Criteria

Inclusion Criteria:

* Subjects male and female aged 60-90
* Subject has a smoking history of \< 0.5 pack years
* Subject understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent
* Subject must be able to perform a breathhold for 16s.
* BMI 18-30
* Subject is judged to be in stable health on the basis of medical history
* Subject able to perform reproducible pulmonary function testing (i.e., the 3 best acceptable spirograms have FEV1 values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater.)

Exclusion Criteria:

* Subject is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material.
* Subject has a history of cardiovascular disorders including coronary insufficiency, cardiac arrhythmias, severe hypertension (≥160 over ≥100)
* Subject has a daytime room air oxygen saturation \<90% while lying supine.
* Subject is unable to perform spirometry or plethysmography maneuvers
* Subject is unable or unwilling to ride a stationary bicycle
* Subject is pregnant
* In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia.
* Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb,