Non-ablative Oligofractionated Radiation Therapy Before Surgical Transplantation As Radiovaccination

Participation Requirements

• Sex:

  ALL

• Eligible Ages:

  18 and up

Participation Criteria

Inclusion Criteria:

* Age ≥ 18
* Patients with end-stage lung disease and suspected stage I primary lung cancer based on CT and PET scan not accessible to curative treatment, including surgery and ablative SBRT.
* Patients with multifocal pulmonary malignancy, including multifocal lung adenocarcinoma, not accessible to curative treatment, including surgery and ablative SBRT.
* Patients with isolated metastases in one or both lungs after complete resection of the primary tumor in the absence of other sites of metastatic disease, not accessible to curative treatment, including surgery and ablative SBRT.
* Meet eligibility criteria for lung transplantation with the exception of the underlying malignancy.
* Subjects must be able to understand the potential risks and benefits of the study and must be able to read and provide written, informed consent for the study.

Exclusion Criteria:

* Age \< 18
* Mediastinal nodes metastasis demonstrated on EBUS-TBNA
* Distant metastasis demonstrated on PET scan or brain imaging.
* Failure to provide informed consent
* Previous thoracic radiation resulting in significant mediastinal or chest wall overlap precluding re-irradiation
* Any other medical condition that, in the opinion of the multidisciplinary team, may interfere with the subject's participation or compliance with the treatment.