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A Study for Observing Severe Asthma in Patients Treated With Tezepelumab

Asthma

A study involving primary data collection within real-world settings of participants who initiate treatment with tezepelumab for severe uncontrolled asthma. This study will complement evidence obtained from randomized controlled trials and provide new data focusing on the holistic and patient reported outcome (PRO).

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Participation Requirements

  • Sex:

    ALL
  • Eligible Ages:

    12 and up

Participation Criteria

Inclusion Criteria:

* Male or female participants aged 12 years or older
* Provision of signed and dated written informed consent, including assent for minors
* Prescribed treatment with Tezepelumab
* Diagnosis of asthma for at least 52 weeks prior to enrolment date and symptoms confirmed by the Investigator not to be due to alternative diagnoses
* Received at least one prescription of medium-dose to high-dose inhaled corticosteroids (ICS) during the 52 weeks prior to enrolment date
* Use of additional asthma maintenance controller medication(s) for at least 52 weeks prior to enrolment date
* Documented history of at least 1 asthma exacerbations during the 52 weeks prior to enrolment date
* Individuals with ACQ-6 score ≥ 1.5 (indicating inadequate asthma symptom control) at enrolment or up to 12 weeks before enrolment
* Participants currently receiving care from pulmonologists and/or allergists
* Participants who are able to understand and complete the ePROs
* Availability of participants medical records for asthma exacerbation and Healthcare Resource Utilization (HCRU) for the 52 weeks prior to Tezepelumab initiation

Exclusion Criteria:

* Any contraindication to Tezepelumab
* Participants on concurrent biologics for asthma at the time of receiving the first dose of Tezepelumab will be excluded except for stable allergen immunotherapy (defined as a stable dose and regimen at the time of enrolment)
* Participation in an observational study that might, in the Investigator's opinion, influence the assessment for the current study, or participation in an interventional clinical trial in the last 3 months
* Pregnancy or lactation period.

Study Location

Research Site
Research Site
Vancouver, British Colombia
Canada

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Research Site
Research Site
Toronto, Ontario
Canada

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Research Site
Research Site
Edmonton, Alberta
Canada

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Research Site
Research Site
Mississauga, Ontario
Canada

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Research Site
Research Site
Saskatoon, Saskatchewan
Canada

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Research Site
Research Site
St. John's, Newfoundland and Labrador
Canada

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Research Site
Research Site
Windsor, Ontario
Canada

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Research Site
Research Site
Calgary, Alberta
Canada

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Research Site
Research Site
Kingston, Ontario
Canada

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Research Site
Research Site
Montr Al,, Qu Bec
Canada

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Study Sponsored By
AstraZeneca
Participants Required
More Information
Study ID: NCT05677139