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Does increased carbon dioxide (CO2) make patients with Postural Tachycardia Syndrome (POTS) feel better?

Postural Orthostatic Tachycardia Syndrome

We are studying if increased carbon dioxide (CO2) can lower heart rate and reduces symptoms in patients with Postural Orthostatic Tachycardia Syndrome (POTS). Participants will perform Supine (lying down) to Stand test under different CO2 levels. We will monitor changes in heart rate and symptoms to determine which intervention is the most effective in minimizing symptoms and lowering heart rate.

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Participation Requirements

  • Sex:

    Male, Female, Intersex

  • Eligible Ages:

    18 to 60

Participation Criteria

Inclusion Criteria:
1- POTS diagnosis or healthy volunteer
2- 18-60 years
3- Non-smoking
4- Able and willing to provide informed consent.
5- Able to travel to Libin Cardiovascular Institute of Alberta Autonomic Testing Lab at the University of Calgary, Calgary, AB.
Exclusion Criteria:
1 - Other causes for increase in heart rate (eg. dehydration)
2 - Pregnant
3 - Inability to tolerate a mask during the study
4 - Require portable oxygen at rest or with exercise
5 - Heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
6 - Participants with severe anxiety

Study Location

University of Calgary
University of Calgary
Calgary, Alberta
Canada

Contact Study Team

Study Sponsored By
University of Calgary
Participants Required
More Information
Study ID: REB20-0135