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Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

Chronic Pain | Knee Pain Chronic | Post Operative Pain

Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

* Patients \>18 years old
* Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee

Exclusion Criteria:

* TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis
* History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency
* Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)
* Language difficulties that would impede valid completion of questionnaires
* Planned staged bilateral TKA
* Treating surgeon deems patient inappropriate for inclusion in trial
* Any allergy or sensitivity to milk
* Pregnant or planning to become pregnant during the study

Lieu de l'étude

Toronto Western Hospital
Toronto Western Hospital
Toronto, Ontario
Canada

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Primary Contact

Anuj Bhatia, MD

[email protected]
Mount Sinai Hospital
Mount Sinai Hospital
Toronto, Ontario
Canada

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Sunnybrook - Holland Centre
Sunnybrook - Holland Centre
Toronto, Ontario
Canada

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Étude parrainée par
University Health Network, Toronto
Participants recherchés
Plus d'informations
ID de l'étude: NCT06123715