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Laryngoscopy for Neonatal and Infant Airway Management with Supplemental Oxygen At Different Flow Rates (OPTIMISE-2)

Airway Management

This study aims to investigate the optimal oxygen flow rate needed during tracheal intubation with the C-MAC video laryngoscope (Karl Storz, Tuttlingen, Germany) using Miller-blade or Macintosh-blade size No. 0 or No. 1 in the operating room or intensive care unit. The investigators hypothesize that the difference between low-flow and high-flow supplemental oxygen is negligible.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    0 to 52

Participation Criteria

Inclusion Criteria:

* Pediatric patients requiring oral or nasal tracheal intubation for elective, semi-elective, or urgent surgical and non-surgical indications.
* Neonates and infants up to 52 weeks postconceptual age, with legal guardians providing written informed consent before the intervention

Exclusion Criteria:

* Prediction of difficult intubation upon physical examination or previous history of difficult intubation, mandating a technique different than direct laryngoscopy to secure the airway;
* Congenital heart disease demanding FiO2 \< 1.0
* Cardiopulmonary collapse requiring advanced life support
* Intubation for emergency surgical and non-surgical indications.

Study Location

Dept. Anesthesia, The Hospital for Sick Children
Dept. Anesthesia, The Hospital for Sick Children
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Clyde Matava, Prof.

Study Sponsored By
Insel Gruppe AG, University Hospital Bern
Participants Required
More Information
Study ID: NCT05967507