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Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients

Postoperative Hemorrhage | Postoperative Blood Loss | Postoperative Anemia

The goal of this pilot trial is to test a protocol for a planned Canada-wide clinical trial looking at whether or not the use of a patients own blood works as good as the current standard of care using donated blood products to reduce blood loss in adult patients having heart surgery.

The main questions this study aims to answer are:

* Is the protocol practical, effective, and efficient.
* Does the use of a patients own blood lower the following: bleeding, the amount donated blood products given, and complications.

Participants will be separated into two groups by a process that is like flipping a coin. One group will donate blood to themselves in the operating room and get their own blood back after surgery. The other group will be given blood products donated by other humans to treat the bleeding after heart surgery.

Researchers will compare both groups to see if patients that get their own blood have fewer donated blood products given at time of heart surgery and have less complications after surgery.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 to 85

Participation Criteria

Inclusion Criteria:

* Adult (≥18 yr)
* Surgical patients at the Mazankowski Alberta Heart Institute
* High risk for acquired coagulopathy

Exclusion Criteria:

* Left ventricular ejection fraction \<20%
* Impaired renal function
* Preoperative anemia (hematocrit \< 30%)
* Abnormal coagulation studies or platelet function
* Presence of hemoglobinopathy
* Platelet count \< 120 10\*9/L
* Non-heparin based CPB anticoagulation
* Presence of carotid stenosis (≥70%)
* Presence of bacteremia/endocarditis
* Age \> 85 yr
* Weight \< 55 kg
* Hepatic failure/dysfunction
* Pregnancy
* Chronic lung disease on home O2
* Acute respiratory failure
* Acute coronary syndromes
* Emergency surgery

Study Location

University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Angela R Neufeld, MD

780-407-8861
Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: NCT05889494