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Checking Blood and Oxygen Flow in the Legs to Help Prevent Wounds

NIRS

People receiving hemodialysis (HD) often experience muscle weakness, low physical function, and delayed wound healing. This may be partly due to poor blood and oxygen flow to the legs during dialysis. This study will use a safe, non-invasive device called near-infrared spectroscopy (NIRS) to measure changes in leg muscle oxygen levels at different points during dialysis. We will also test how the muscles respond to light exercise (cycling), leg movements, and brief blood flow changes. This small, proof-of-concept study will help us understand if dialysis reduces leg oxygenation and whether exercise during dialysis can improve it.

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Participation Requirements

  • Sex:

    Any

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:
Who can take part in this study:
Adults aged 18 years and older (there is no maximum age limit).
Individuals who are considered safe and able to exercise, as determined by the study doctor or a trained exercise specialist.
Individuals who do not have serious leg issues (such as open sores, skin problems, or severe blood flow problems in the legs) that would make it unsafe to briefly restrict blood flow using a pressure cuff.
Individuals who have a detectable pulse in the foot of the leg being tested (this may be checked using a small device called a Doppler).
Individuals who do not have significant swelling in the leg being tested, which might affect how well the oxygen sensor works.
Individuals who are able to understand the study procedures, follow instructions, and give written consent to participate (this can include the help of a translator if needed).
Exclusion Criteria:
Who cannot take part in this study:
You may not be able to participate in the study if:
You have had unstable blood pressure during dialysis over the past month—for example, very high blood pressure (above 180/100) or very low blood pressure (below 90/40) that causes symptoms like dizziness or fainting.
You’ve had a heart attack or other serious heart problem in the last 3 months.
You have a heart rhythm problem that is not under control.
You feel short of breath even when resting or doing very little activity.
You are unable to lift your legs (even with help), due to pain (like severe sciatica) or a previous injury.
The study doctor feels that participating may not be safe or appropriate for you—for example, if you have not been following your regular treatment or check-ups.

Study Location

University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contact Study Team

Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: Pro00153727