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Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers

E Cigarette Use

This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    16 and up

Participation Criteria

Inclusion Criteria:

* Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed.
* Male and female participant age ≥16 years.
* Participant has recently started vaping, \>1 and \<5 years weekly use.
* 70 participants will be c-cigarette never users.
* 70 participants will be former or current c-cigarette users.
* 10 asymptomatic age and sex-matched healthy people who have never used e- or c-cigarettes will be controls.

Exclusion Criteria:

* Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia.
* Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material.
* Participant unable to perform spirometry or plethysmography maneuvers.

Study Location

Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
London, Ontario
Canada

Contact Study Team

Primary Contact

Grace E Parraga, PhD

[email protected]
519-931-5265
Study Sponsored By
Western University, Canada
Participants Required
More Information
Study ID: NCT04616313