Effects of 5HTP on the Injured Human Spinal Cord
Spinal Cord InjuriesThis study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.
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Participation Requirements
-
Sex:
ALL -
Eligible Ages:
18 to 65
Participation Criteria
Inclusion Criteria:
* participants must have suffered trauma to the spinal cord at least six months ago or longer
Exclusion Criteria:
* individuals with damage to the nervous system other than to the spinal cord
* pregnant and/or breastfeeding women
* alcoholic participants
* history of seizure/epilepsy
* history of suicidal thoughts or behaviors
* known or suspected allergy to the medication ingredients
* cardiovascular disease including history of heart attack or heart rhythm irregularities
* coronary artery disease
* reduced liver function or disease
* reduced kidney function or disease
* lung disease
* comatose or depressed states due to CNS depressants
* endocrine dysfunction
* blood dyscrasias or blood related disease
* bone marrow depression
* hypocalcemia
* history of stomach ulcers
* wide angle glaucoma
* phenylketonuria
* history of tumors
* uncontrolled heart problems
* unstable psychiatric or mental disorder
Participants taking:
* monoamine oxidase inhibitor therapy
* serotonergic antidepressants
* tricyclic antidepressants
* any type of serotonergic agonist
* dopamine D2 receptor antagonists
* amphetamine
* CNS depressants
* levodopa
* lithium
* anti-hypertensive drugs
* iron salts
* metoclopramide
* phenothiazine medication
Study Location
University of Alberta
University of AlbertaEdmonton, Alberta
Canada
Contact Study Team
- Study Sponsored By
- University of Alberta
- Participants Required
- More Information
- Study ID:
NCT04520178