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Prospective Evaluation of Breast-Conserving Surgery Alone in Low-Risk Ductal Carcinoma in Situ (DCIS)

DCIS

To evaluate whether the combination of clinicopathological factors and the use of the Oncotype DX DCIS score can avoid radiation in women with low risk DCIS who have had breast conserving surgery (BCS)

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Participation Requirements

  • Sex:

    FEMALE

  • Eligible Ages:

    46 and up

Participation Criteria

Inclusion Criteria:

1. Female patient \> 45 years of age with DCIS without microinvasion.
2. Tumour size ≤ 2.5cm.
3. Treated by BCS with clear resection margins ≥ 2 mm or no residual disease on re-excision.\*

\* Patients with anterior margins and posterior margins ≥1 mm are eligible. Or if the dissection was confirmed to be taken to skin and down to fascia with no DCIS present at inked margins.
4. Oncotype DX DCIS score with a predicted 10-year risk of LR ≤10%.

Exclusion Criteria:

1. Multifocal DCIS.
2. History of any invasive breast cancer or non-invasive breast cancer in the ipsilateral breast.
3. Synchronous or previous invasive or non-invasive breast cancer.
4. Prior history of invasive cancer within the last 5 years, excluding non-melanoma skin cancers.
5. ECOG performance status ≥3.
6. Life expectancy \<10 years.
7. Geographic inaccessibility for follow-up.

Study Location

Arthur J.E. Child Comprehensive Cancer Centre
Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Payal Thakkar

[email protected]
BC Cancer - Fraser Valley Centre
BC Cancer - Fraser Valley Centre
Surrey, British Columbia
Canada

Contact Study Team

Primary Contact

Noelle Baird

[email protected]
604-587-4315
Cape Breton Cancer Centre
Cape Breton Cancer Centre
Sydney, Nova Scotia
Canada

Contact Study Team

Primary Contact

Alexandra Szeto

[email protected]
Sunnybrook Health Science Centre -Odette Cancer Centre
Sunnybrook Health Science Centre -Odette Cancer Centre
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Clarissa Chau

[email protected]
Jewish General Hospital
Jewish General Hospital
Montréal, Quebec
Canada

Contact Study Team

BC Cancer - Centre for the North (Prince George)
BC Cancer - Centre for the North (Prince George)
Prince George, British Columbia
Canada

Contact Study Team

Primary Contact

Sarah Zuccaro

[email protected]
QE II HSC - Nova Scotia Cancer Centre
QE II HSC - Nova Scotia Cancer Centre
Halifax, Nova Scotia
Canada

Contact Study Team

Primary Contact

Jessica Boddy

[email protected]
Regional Cancer Care, Thunder Bay Regional Health Sciences Centre
Regional Cancer Care, Thunder Bay Regional Health Sciences Centre
Thunder Bay, Ontario
Canada

Contact Study Team

Primary Contact

Lori Moon

[email protected]
CHUM - Centre Hospitalier de L'Université de Montréal
CHUM - Centre Hospitalier de L'Université de Montréal
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Silvine Benth

[email protected]
Centre Intégré Universitaire de Santé et de Services Sociaux de la Mauricie- Centre-du-Québec (CIUSSS MCQ) - Trois-Rivières
Centre Intégré Universitaire de Santé et de Services Sociaux de la Mauricie- Centre-du-Québec (CIUSSS MCQ) - Trois-Rivières
Trois-Rivières, Quebec
Canada

Contact Study Team

Primary Contact

Marie-Eve Caron

[email protected]
Cross Cancer Institute
Cross Cancer Institute
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Andrea Rosario

[email protected]
BC Cancer - Vancouver Centre
BC Cancer - Vancouver Centre
Vancouver, British Columbia
Canada

Contact Study Team

Primary Contact

Fermin Hoq

[email protected]
Juravinski Cancer Centre
Juravinski Cancer Centre
Hamilton, Ontario
Canada

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Primary Contact

Brenda DeMedeiros

[email protected]
University Health Network - Princess Margaret Cancer Centre
University Health Network - Princess Margaret Cancer Centre
Toronto, Ontario
Canada

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Primary Contact

Lea Dungao

[email protected]
McGill University Health Centre
McGill University Health Centre
Montréal, Quebec
Canada

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Primary Contact

Marianna Perna

[email protected]
BC Cancer - Abbotsford Centre
BC Cancer - Abbotsford Centre
Abbotsford, British Columbia
Canada

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Primary Contact

Sukhpreet Sidhu

[email protected]
604-851-4710
BC Cancer - Victoria
BC Cancer - Victoria
Victoria, British Columbia
Canada

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Primary Contact

Lily Hallett Rio

[email protected]
London Regional Cancer Program
London Regional Cancer Program
London, Ontario
Canada

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Primary Contact

Alisha Moynahan

[email protected]
Hôpital Charles Le Moyne (CISSS de la Montérégie-Centre)
Hôpital Charles Le Moyne (CISSS de la Montérégie-Centre)
Greenfield Park, Quebec
Canada

Contact Study Team

Primary Contact

Caroline Hivon

[email protected]
Centre intégré de cancérologie du CHU de Québec - Université Laval
Centre intégré de cancérologie du CHU de Québec - Université Laval
Québec City, Quebec
Canada

Contact Study Team

Primary Contact

Josée Allard

[email protected]
Study Sponsored By
Ontario Clinical Oncology Group (OCOG)
Participants Required
More Information
Study ID: NCT04797299