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Analysis of human pituitary tumor tissues

Acromegaly | Pituitary Adenoma | Pituitary Tumor | Cushing's Disease

Pituitary tumors are a type of brain tumors. Large pituitary tumors can cause headaches and eye problems. Unbalance of hormones by pituitary tumors can cause several complications, such as diabetes, obesity, etc. As there are limited treatment options, we need new treatment options. Our data from mouse and rat pituitary tumor cells suggest some molecules and signals as possible treatment targets. As these cells do not fully mimic human cells, we will use pituitary tumor cells from patients. We will examine the effects of inhibition of the target molecules on cell functions, such as cell growth, hormone production, in cultured human pituitary tumor cells. Findings will lead to the establishment of new treatment options for pituitary tumors.

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Participation Requirements

  • Sex:

    Any

  • Eligible Ages:

    18 to 75

Participation Criteria

Inclusion Criteria:
Participants must meet all of the following criteria to be eligible for inclusion in this study.
1) Written informed consent must be obtained before pituitary surgery.
2) Male, female, or intersex patients aged 18 - 75 years.
3) Participants must have confirmed pituitary tumor(s) that require pituitary surgery to treat the condition.
a. MRI confirmation of pituitary tumor > 10 mm pushing up the optic nerve
or
b. Endocrinological investigations before pituitary surgery confirm excess of pituitary hormone(s) and MRI confirmation of pituitary tumor except prolactin-producing pituitary tumor.
or
c. prolactin-producing pituitary tumor with resistance to medical treatment
Exclusion Criteria:
Participants meet any of the following criteria are not eligible for inclusion in this study.
1) Patients who do not provide informed consent.
2) Patients aged <18 years, >75 years

Study Location

University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Toru Tateno

[email protected]
780-492-3626
Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: Pro00091514