Fish Oil, Metformin and Heart Health in PCOS
Cardiovascular Disease | PCOS | Atherosclerotic Cardiovascular Disease | Atherosclerotic Plaque | Cardiac HypertrophyWomen with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes.
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Participation Requirements
-
Sex:
FEMALE -
Eligible Ages:
25 to 45
Participation Criteria
Inclusion Criteria:
* diagnosis of PCOS
* overweight-obese (BMI \>25 kg/m2)
* elevated fasting plasma TG (\>150 mg/dL)
* and/or apoB48-remnant cholesterol lipoproteins (\>20 ug/ml)
* impaired insulin sensitivity (glucose 100-125 mg/dL and/or insulin \>15 (uM/ml), and may be diagnosed with T2D (blood glucose \>126 mg/dL).
Exclusion Criteria:
-pregnancy, lactation
Study Location
University of Alberta Hospital - Division of Endocrinology
University of Alberta Hospital - Division of EndocrinologyEdmonton, Alberta
Canada
Contact Study Team
Beate Sydora
Human Nutrition Research Unit - Li Ka Shing Health Research Center
Human Nutrition Research Unit - Li Ka Shing Health Research CenterEdmonton, Alberta
Canada
Contact Study Team
Mazankowski Alberta Heart Institute
Mazankowski Alberta Heart InstituteEdmonton, Alberta
Canada
Contact Study Team
- Study Sponsored By
- University of Alberta
- Participants Required
- More Information
- Study ID:
NCT06424860