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Dexamethasone for Reduction of Post Thoracotomy Pain Syndrome

Chronic Pain | Thoracic Surgery | Cytokines | Dexamethasone

Post thoracotomy pain syndrome still affects 50% of patients after a thoracic surgery. Pathogenesis is unclear but there is growing evidence that neuro inflammation may play a significant role. Dexamethasone is a very potent anti-inflammatory drug. The hypothesis of this study is that dexamethasone, given pre operatively, would help reduce the incidence of post thoracotomy pain syndrome 3 months after surgery, by reducing the inflammatory response, in patients undergoing elective thoracic surgery that includes thoracic epidural analgesia.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 to 75

Participation Criteria

Inclusion Criteria:

* elective thoracic surgery using a thoracotomy incision and thoracic epidural analgesia
* ASA I-III
* age 18-75 yo

Exclusion Criteria:

* contra-indication to thoracic epidural analgesia
* patient refusal
* patients already taking cortisone or dexamethasone
* patients on chronic opioid medication

Study Location

Maisonneuve-Rosemont Hospital
Maisonneuve-Rosemont Hospital
Montreal, Quebec
Canada

Contact Study Team

Primary Contact

Brulotte Veronique, MD, MSc

[email protected]
514 252-3400
Study Sponsored By
Maisonneuve-Rosemont Hospital
Participants Required
More Information
Study ID: NCT02112864