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Fetal Brain Growth - Pilot Study

Preterm Labor | Maternal Psychological Distress

The goal of this observational prospective study is to explore the feasibility of measuring fetal and neonatal brain growth using 2D and 3D ultrasound in fetuses exposed to threatened preterm labor (TPTL) and antenatal corticosteroids (ACS) compared to non-exposed fetuses.

Patients with singleton pregnancies on our site with repeated ultrasound measurements every 4 weeks will be evaluated for fetal brain development. The exposed group is defined as patients with a dual exposure of TPTL and ACS. The non-exposed group will be composed of patients who did not have TPTL and ACS. Therefore, patients will have a maximum of 5 additional visits (4 that will occur prenatally and 1 postnatal visit).

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Participation Requirements

  • Sex:

    FEMALE

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

Exposed group - TPL and ACS:

* 22-34 weeks and 6 days gestation at time of recruitment.
* Threatened preterm labor (TPTL)
* Administration of a partial or full course of ACS.
* Admission to the MUHC-RVH birthing center or the antenatal floor (D6S).
* Delivery planned at the MUHC-RVH or an institution around the Greater Montreal Area.

Non-exposed group:

* At or prior to 22 weeks gestation at time of recruitment.
* Delivery planned at the MUHC-RVH.

Exclusion Criteria:

* Major congenital anomalies, suspected fetal syndrome or genetic disease, or intra-uterine fetal growth restriction.
* Significant maternal disease which may cause preterm delivery or fetal growth restriction (e.g., severe infection, uncontrolled hypertension or diabetes).
* Patients who received more than one course of ACS prior to enrollment.
* Patients on any oral or other systemic corticosteroids, with the exception of inhaled corticosteroids.
* BMI over 35.

Study Location

McGill University Health Centre
McGill University Health Centre
Montréal, Quebec
Canada

Contact Study Team

Primary Contact

Daniela Villegas M., MSc

[email protected]
514-412-4400
Study Sponsored By
McGill University Health Centre/Research Institute of the McGill University Health Centre
Participants Required
More Information
Study ID: NCT05994443