Treatment In Thoracic Aortic Aneurysm: Surgery vs. Surveillance (TITAN: SvS)

Participation Requirements

• Sex:

  Any

• Eligible Ages:

  18 to 79

Participation Criteria

Inclusion Criteria:
Inclusion Criteria:

1) Patients between the age of 18 and 79 inclusive.
2) Ascending aortic aneurysm between 5.0cm and 5.4cm in maximal diameter as measured by CT with contrast.
3) Patients with ascending aortic aneurysm with a diameter of 4.5 cm - 4.9 cm will be clinically monitored with serial CTs, and will be considered for enrollment into the trial once the aneurysm reaches 5.0 cm.
Exclusion Criteria:
Exclusion Criteria:
1) Patients who refused to be randomized (these patients can enroll in the study registry)
2) Patients who are symptomatic, attributable to ascending aortic aneurysms
3) Previous cardiac surgery
4) Patients whose primary indication for cardiac surgery is non-AsAA related
5) Ascending aortic and arch aneurysm with descending thoracic aorta involvement
6) Patients with known connective tissue disease (E.g. Marfan syndrome, Loey-Dietz syndrome, Turner syndrome etc) syndrome, etc.
7) Patients with possible genetic aortopathies (eg known family history of aortic aneurysms/premature aortic dissections/ruptures)
8) Patients who, in the opinion of the investigator, are deemed unfit for surgery for reasons that may include: Severe pulmonary disease; Severe kidney disease; MI within the last 6 months; Major surgical procedure or angioplasty within 3 months; Expected survival less than 5 years because of other disease (e.g. invasive cancer)